Synaptic interactions to extract information about wavelength, and thus color, begin in the
vertebrate retina with three classes of light-sensitive cells: rod photoreceptors at low light …

Retinal gene supplementation therapy such as the first approved one, voretigene
neparvovec, delivers a functioning copy of the missing gene enabling the protein …

Retinal drusen formation is not only a clinical hallmark for the development of age-related
macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and …

We have used recent measurements of mammalian cone light responses and voltage-gated
currents to calculate cone ATP utilization and compare it to that of rods. The largest …

Neuromodulators such as dopamine, enable context-dependent plasticity of neural circuit
function throughout the central nervous system. For example, in the retina, dopamine tunes …

The stretching of a myopic eye is associated with several structural and functional changes
in the retina and posterior segment of the eye. Recent research highlights the role of retinal …

Background Voretigene neparvovec is a gene therapeutic agent for treatment of retinal
dystrophies caused by bi-allelic RPE65 mutations. In this study, we report on a novel and …

Photoreceptor cell transplantation into the mouse retina has been shown to result in the
transfer of cytoplasmic material between donor and host photoreceptors. Recently it has …

Circadian rhythms are biological rhythms that originate from the “master circadian clock,”
called the suprachiasmatic nucleus (SCN). SCN orchestrates the circadian rhythms using …

Vision is an important sense for humans, and visual impairment/blindness has a huge
impact in daily life. The retina is a nervous tissue that is essential for visual processing since …