Alzheimer's disease and other tauopathies have recently been clustered with a group of
nervous system disorders termed protein misfolding diseases. The common element …

Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated
from the orthosteric binding site for the endogenous neurotransmitter. Allosteric modulators …

What is the most fundamental concept in toxicology? Is there a most fundamental concept in
toxicology? If there is, would it affect how toxicology is taught, how textbooks are written and …

Biochemical characterization of the muscarinic receptors Page 145 BIOCHEMICAL
CHARACTERIZATION OF THE MUSCARINIC RECEPTORS By MORDECHAI …

Cardiac glycosides inhibit the Na, K-ATPase by binding to the catalytic alpha subunit of the
enzyme. Site-directed mutagenesis of the H1-H2 domain has demonstrated the importance …

After short preincubations withN-[3 H] methylscopolamine ([3 H] NMS) orR (−)-[3 H]
quinuclidinyl benzilate ([3 H] QNB), radioligand dissociation from muscarinic M 1 receptors …

The binding of agonist (carbachol) and antagonist (atropine) to the rat heart atrial muscarinic
cholinergic receptor sites was investigated. 2. Divalent cations (Mg 2+ or Ca 2+), in low …

Interaction of orthosteric ligands with extracellular domain was described at several
aminergic G protein-coupled receptors, including muscarinic acetylcholine receptors. The …

The kinetic mechanism of super high affinity [3H] oxotremorine M binding to porcine m2
muscarinic receptors expressed in Chinese hamster ovary cells was examined. In cell lines …

The mode of interaction of bisquaternary pyridinium oximes with rat brain muscarinic
receptors in cerebral cortex and brain stem preparations was studied by the use of the tritium …