Prenatal environmental exposures, epigenetics, and disease
F Perera, J Herbstman - Reproductive toxicology, 2011 - Elsevier
This review summarizes recent evidence that prenatal exposure to diverse environmental
chemicals dysregulates the fetal epigenome, with potential consequences for subsequent …
chemicals dysregulates the fetal epigenome, with potential consequences for subsequent …
Oxidative stress in schizophrenia: an integrated approach
BKY Bitanihirwe, TUW Woo - Neuroscience & Biobehavioral Reviews, 2011 - Elsevier
Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia.
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …
Epigenetics and bacterial infections
Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …
during development or orchestrate cellular responses to external stimuli. Recent studies …
DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression
M Fuchikami, S Morinobu, M Segawa, Y Okamoto… - PloS one, 2011 - journals.plos.org
Major depression, because of its recurring and life-threatening nature, is one of the top 10
diseases for global disease burden. Major depression is still diagnosed on the basis of …
diseases for global disease burden. Major depression is still diagnosed on the basis of …
Epigenetic regulation of gene expression in physiological and pathological brain processes
Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …
an integral part of a multitude of brain functions that range from the development of the …
[HTML][HTML] Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene …
AT Nguyen, TA Rauch, GP Pfeifer, VW Hu - The FASEB Journal, 2010 - ncbi.nlm.nih.gov
Autism is currently considered a multigene disorder with epigenetic influences. To
investigate the contribution of DNA methylation to autism spectrum disorders, we have …
investigate the contribution of DNA methylation to autism spectrum disorders, we have …
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific …
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an
estimation of the relative contribution of genetic and shared and nonshared environmental …
estimation of the relative contribution of genetic and shared and nonshared environmental …
Epigenetic principles and mechanisms underlying nervous system functions in health and disease
MF Mehler - Progress in neurobiology, 2008 - Elsevier
Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …
are already providing unique insights into the mechanisms underlying brain development …
DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker
J Tost - Molecular biotechnology, 2010 - Springer
DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …
Epigenetics of dementia: understanding the disease as a transformation rather than a state
Alzheimer's disease and other idiopathic dementias are associated with epigenetic
transformations. These transformations connect the environment and genes to …
transformations. These transformations connect the environment and genes to …