Matrine exerts a strong anti-arthritic effect on type II collagen-induced arthritis in rats by inhibiting inflammatory responses

J Pu, FF Fang, XQ Li, ZH Shu, YP Jiang, T Han… - International journal of …, 2016 - mdpi.com
To investigate anti-arthritic effects of matrine isolated from the roots of S. flavescens on type
II collagen-induced arthritis (CIA) in rats and to explore its related potential mechanisms, CIA …

Curculigoside exerts significant anti‑arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF‑κB signaling pathway

S Tan, J Xu, A Lai, R Cui, R Bai… - Molecular …, 2019 - spandidos-publications.com
The present study aimed to investigate the anti‑arthritic effects of curculigoside isolated from
the rhizome of Curculigo orchioides Gaertn in vivo and in vitro, as well as to determine the …

The expression of P2X7 receptor on Th1, Th17, and regulatory T cells in patients with systemic lupus erythematosus or rheumatoid arthritis and its correlations with …

M Li, C Yang, Y Wang, W Song, L Jia… - The Journal of …, 2020 - journals.aai.org
Abstract P2X7 receptor (P2X7R) is highly expressed on immune cells, triggering the release
of cytokines and regulating autoimmune responses. To investigate P2X7R surface …

Gene expression and six single nucleotide polymorphisms of interleukin-6 in rheumatoid arthritis: A case-control study in Iraqi patients

AH Ad'hiah, AS Mahmood, AKA Al-kazaz… - Alexandria journal of …, 2018 - ajol.info
Background: Interleukin-6 (IL-6) plays a significant role in pathogenesis of rheumatoid
arthritis (RA), but its single nucleotide polymorphisms (SNPs), as well as therapy may …

A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS

T Xu, S Liu, J Zhao, G Feng, Z Pi, F Song… - Molecular BioSystems, 2015 - pubs.rsc.org
The Wu-tou formula (WTF) is a Chinese medicine formula which has been applied to treat
rheumatic arthritis (RA) and pain of joints for more than a thousand years. In this study, a …

[PDF][PDF] The association of genetic polymorphisms in tumor necrosis factor-alpha and interleukins with disease severity or response to biological therapy in Iraqi …

SI Mohammed, MY Jamal, IO Alshamari - Al-Rafidain Journal of Medical …, 2023 - iasj.net
Background: Tumor necrosis factor-alpha (TNF-α) and interleukins play important roles in
the pathogenesis of rheumatoid arthritis (RA). Genetic research has been employed to find …

Rheumatoid arthritis autologous synovial fluid affects the plasticity and function of peripheral and induced T regulatory cells in vitro

V Kommoju, CM Mariaselvam, SN Bulusu… - Immunology …, 2024 - Elsevier
The synovial fluid (SF) microenvironment in rheumatoid arthritis (RA) may alter the stability
and function of Tregs. In the present study, we assessed cytokine levels and percentage of …

[PDF][PDF] Gene expression and polymorphism of interleukin-4 in a sample of Iraqi rheumatoid arthritis patients

AH Ad'hiah, AS Mahmood, AKA Al-Kazaz… - Baghdad Science …, 2018 - iasj.net
It was aimed to understand the interleukin-4 (IL-4) role in etio-pathogenesis of rheumatoid
arthritis (RA). Two approaches were adopted. In the first one, a quantitative expression of IL4 …

Anti-arthritic effect of total anthraquinone from Polygonum cuspidatum on type II collagen-induced arthritis in rats

F Wang, Y Qiao, H Niu, H Zhao - Tropical Journal of Pharmaceutical …, 2017 - ajol.info
Purpose: To study the anti-arthritic effect of total anthraquinone from Polygonum cuspidatum
(TAPC) on type II collagen-induced arthritis (CIA) in rats, and to investigate the underlying …

[PDF][PDF] 血清IL-2, TNF-α 及IL-13 在类风湿关节炎诊断与治疗中的临床意义

杨荣敏, 段相国, 陈建, 刘河涛, 崔建健, 苏春霞 - 现代免疫学, 2017 - shmy.shsmu.edu.cn
为探讨血清IL-2, TNF-α 及IL-13 在类风湿关节炎(rheumatoidarthritis, RA) 诊断与治疗中的临床
意义, 收集了30 例RA 患者外周血, 其中经过常规治疗的患者27 例, 常规治疗合并生物制剂治疗 …