Different immunoregulation roles of activin A compared with TGF-β

F Li, Y Long, X Yu, Y Tong, L Gong - Frontiers in Immunology, 2022 - frontiersin.org
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a
pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases …

Acute pancreatitis: pathogenesis and emerging therapies

S Zaman, F Gorelick - Journal of pancreatology, 2024 - journals.lww.com
Acute pancreatitis is a severe inflammatory disorder with limited treatment options. Improved
understanding of disease mechanisms has led to new and potential therapies. Here we …

Non-canonical activin A signaling stimulates context-dependent and cellular-specific outcomes in CRC to promote tumor cell migration and immune tolerance

MB Wiley, J Bauer, K Mehrotra, J Zessner-Spitzenberg… - Cancers, 2023 - mdpi.com
Simple Summary The identification of markers of metastatic disease is critical to improving
colorectal cancer survival rates. Activin A plays a critical role in tumor and immune cells in …

Role of stromal activin A in human pancreatic cancer and metastasis in mice

G Mancinelli, C Torres, N Krett, J Bauer… - Scientific reports, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains
one of the cancers with the highest mortality rates. Activin A has been implicated in colon …

Oral subacute nephrotoxicity of aristololactam I in rats

C Wang, Y Zhang, D Chen, H Weng, H Li, Y Lu - Toxicology, 2022 - Elsevier
Aristolactams (ALs) have been recognized as one kind of metabolites of aristolochic acids
(AAs), the nephrotoxic components of Aristolochiaceae plants, and are more widely …

Acute pancreatitis: Current clinical approaches, molecular pathophysiology, and potential therapeutics

MB Wiley, K Mehrotra, J Bauer, C Yazici… - Pancreas, 2023 - journals.lww.com
Objective Severe acute pancreatitis (SAP), pancreatic inflammation leading to multiorgan
failure, is associated with high morbidity and mortality. There is a critical need to identify …

Nano‐curcumin supplementation in patients with mild and moderate acute pancreatitis: A randomized, placebo‐controlled trial

M Chegini, A Sadeghi, F Zaeri, M Zamani… - Phytotherapy …, 2023 - Wiley Online Library
We aimed to investigate whether nano‐curcumin as an anti‐inflammatory agent is effective
in patients with mild and moderate AP. This study was a double‐blind, parallel‐arm …

Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis

MB Wiley, J Bauer, V Alvarez, K Mehrotra, W Cheng… - Scientific Reports, 2024 - nature.com
Acute Pancreatitis (AP) is associated with high mortality and current treatment options are
limited to supportive care. We found that blockade of activin A (activin) in mice improves …

Dynamic Changes in Serum Cytokine Profile in Rats with Severe Acute Pancreatitis

R Zhou, W Bu, Y Fan, Z Du, J Zhang, S Zhang, J Sun… - Medicina, 2023 - mdpi.com
Background and Objectives: Most published research has only investigated a single
timepoint after the onset of severe acute pancreatitis (SAP), meaning that they have been …

[HTML][HTML] Activin A as a Potential Biomarker for Preserved Ratio Impaired Spirometry (PRISm) and Clinical Outcomes in Community-Dwelling Adults

CY Sun, WJ Lee, HC Shen, WK Yu, WC Chen… - Archives of Gerontology …, 2024 - Elsevier
Introduction: This study endeavors to decipher the association between Activin A and
PRISm, thereby addressing the potential of Activin A as a serum biomarker for early …