The lab of Jürg Tschopp was the first to report on the crucial role of receptor-interacting
protein kinase 1 (RIPK1) in caspase-independent cell death. Because of this pioneer …

Hair follicle (HF) development is the result of neuroectodermal–mesodermal interactions,
and can be divided into morphologically distinguishable stages (induction, organogenesis …

The molecular basis of X-linked recessive anhidrotic ectodermal dysplasia with
immunodeficiency (EDA-ID) has remained elusive. Here we report hypomorphic mutations …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Hypohidrotic and anhidrotic ectodermal dysplasia (HED/EDA) is a rare genodermatosis
characterized by abnormal development of sweat glands, teeth, and hair. Three disease …

Drosophila provides a powerful genetic model for studying the in vivo regulation of cell
death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate …

Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development
and disease, but how these pathways intersect is unclear. Using hair follicle induction as a …

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-
mesenchymal interactions. These processes involve a series of inductive and permissive …

Members of the tumour-necrosis factor receptor (TNFR) family that contain an intracellular
death domain initiate signalling by recruiting cytoplasmic death domain adapter proteins …

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of
scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling …