The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The vast increase in Alzheimer disease (AD) worldwide has grave implications for
individuals, family support systems and the health-care systems that will attempt to cope with …

Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

Background The literature regarding clinical olfaction, olfactory loss, and olfactory
dysfunction has expanded rapidly over the past two decades, with an exponential rise in the …

Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Objective We aimed to examine whether impaired olfaction is associated with cognitive
decline and indicators of neurodegeneration in the brain of dementia-free older adults …

The US NHANES included chemosensory assessments in the 2011–2014 protocol. We
provide an overview of this protocol and 2012 olfactory exam findings. Of the 1818 NHANES …

Like other sensory systems, olfactory function deteriorates with age. Epidemiological studies
have revealed that the incidence of olfactory dysfunction increases at the age of 60 and …

The only drugs currently approved for the treatment of Alzheimer's Disease (AD) are four
acetylcholinesterase inhibitors and the NMDA antagonist memantine. Apart from these …

Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction
is one of the early signs of prodromal neurodegenerative diseases such as Alzheimer's and …