Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor and is
associated with a poor clinical prognosis. Despite the progress in the understanding of the …

The majority of patients with common malignancies are older adults. Intrinsic complex
biological changes of aging along with inflammation, immunosenescence, age-associated …

Survival for patients with glioblastoma, the most common high-grade primary CNS tumor,
remains poor despite multiple therapeutic interventions including intensifying cytotoxic …

Glioblastoma multiforme (GBM) is one of the most aggressive human brain malignancies.
Even with optimal treatment, median survival is less than 6 months for patients with recurrent …

Little progress has been made in the long-term management of glioblastoma multiforme
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …

Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …

Human Cytomegalovirus (HCMV) is an immensely pervasive herpesvirus, persistently
infecting high percentages of the world population. Despite the apparent robust host …

Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How
cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment …