Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Mutations in the E3 ubiquitin ligase parkin are the most common cause of early-onset
Parkinson's disease (PD). Although parkin modulates mitochondrial and endolysosomal …

Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …

Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …

Neurons rely mostly on mitochondria for the production of ATP and Ca2+ homeostasis. As
sub-compartmentalized cells, they have different pools of mitochondria in each compartment …

Mitochondria are unique and essential organelles that mediate many vital cellular processes
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …

Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one
etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …