It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are usually associated with
loss of dopaminergic neurons. Loss of substantia nigra neurons and presence of Lewy body …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Abstract α-synuclein is a neuronal protein implicated genetically in Parkinson's disease. α-
synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that α …

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of
Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein …

A novel mutation in the α-Synuclein (α-Syn) gene “G51D” was recently identified in two
familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy …

In Parkinson disease (PD), affected midbrain dopamine (DA) neurons lose specific
dopaminergic properties before the neurons die. How the phenotype of DA neurons is …

The presynaptic protein α-synuclein has a central role in Parkinson's disease (PD).
However, the mechanism by which the protein contributes to neurodegeneration and its …

Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation
of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has …

The misfolding, amyloid aggregation, and fibril formation of intrinsically disordered
proteins/peptides (or amyloid proteins) have been shown to cause a number of disorders …