The bone fracture cases have been increasing yearly, accompanied by the increased
number of patients experiencing non-union or delayed union after their bone fracture …

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …

Realizing the potential application of chitosan as an effective biomedical hemostatic agent
has become an emerging research hotspot. However, fabricating a flexible chitosan-based …

Osteoporosis is the most common degenerative orthopedic disease in the elderly. Recently,
the therapeutic methods for osteoporosis have shifted towards the regulation of local …

Intermittent delivery of parathyroid hormone (PTH) could effectively promote bone
regeneration, but the need for daily injection administration has limited its further clinical …

Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real
clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents …

Iron is one of the essential mineral elements for the human body and this nutrient deficiency
is a worldwide public health problem. Iron is essential in oxygen transport, participates in …

Background Traditionally, nanoparticles for biomedical applications have been produced via
the classical wet chemistry method, with size control remaining a major problem in drug …

This review focuses on the current knowledge on the involvement of metal ions in signaling
processes within the cell, in both physiological and pathological conditions. The first section …

Ferumoxytol, approved by the US Food and Drug Administration in 2009, is one of the
intravenous iron oxide nanoparticles authorized for the treatment of iron deficiency in …