Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Toxicokinetics, dose–response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives

Q Chen, JE Riviere, Z Lin - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
The rapid growth of nanomaterial applications has raised safety concerns for human health.
A number of studies have been conducted to assess the toxicokinetics, toxicology, dose …

Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach

YH Cheng, C He, JE Riviere, NA Monteiro-Riviere… - ACS …, 2020 - ACS Publications
Numerous studies have engineered nanoparticles with different physicochemical properties
to enhance the delivery efficiency to solid tumors, yet the mean and median delivery …

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

W Zhao, Y Cong, HM Li, S Li, Y Shen, Q Qi… - Natural Product …, 2021 - pubs.rsc.org
Covering: up to 2020 As a main bioactive component of the Chinese, Indian, and American
Podophyllum species, the herbal medicine, podophyllotoxin (PTOX) exhibits broad spectrum …

[PDF][PDF] Nanoparticles based on hydrophobic polysaccharide derivatives—formation principles, characterization techniques, and biomedical applications

M Gericke, P Schulze, T Heinze - Macromolecular Bioscience, 2020 - db-thueringen.de
Polysaccharide (PS) nanoparticles (NP) are intensively studied in various branches of basic
and applied sciences; from polymer chemistry over material research to advanced …

Theranostic nanoplatform: triple-modal imaging-guided synergistic cancer therapy based on liposome-conjugated mesoporous silica nanoparticles

Q Sun, Q You, J Wang, L Liu, Y Wang… - … applied materials & …, 2018 - ACS Publications
Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a
versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd) …

Insight into the molecular mechanism of podophyllotoxin derivatives as anticancer drugs

H Fan, Z Zhu, H Xian, H Wang, B Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Podophyllotoxin (PTOX) is a biologically active compound derived from the podophyllum
plant, and both it and its derivatives possess excellent antitumor activity. The PTOX …

Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy

Y Li, M Chen, B Yao, X Lu, X Zhang, P He… - Journal of materials …, 2019 - pubs.rsc.org
Podophyllotoxin (PPT), a toxic polyphenol extracted from the roots of Podophyllum species,
showed remarkable activity against P-glycoprotein (P-gp) mediated multidrug resistant …

Self-assembly of podophyllotoxin-loaded lipid bilayer nanoparticles for highly effective chemotherapy and immunotherapy via downregulation of programmed cell …

R Wang, Y Zhao, Z Huang, Y Zhou, W Wang, Y Xuan… - ACS …, 2022 - ACS Publications
Low drug delivery efficiency elevates the cost of medication, lowers the therapeutic efficacy,
and appears as a leading reason for unmet needs in anticancer therapies. Herein, we report …

[HTML][HTML] Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Z Wang, L Yang - Pharmacological Research, 2024 - Elsevier
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …