Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Recent biochemical observations have helped redefine antigenic components within the
voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now …

Background Voltage-gated potassium channels are thought to be the target of antibodies
associated with limbic encephalitis. However, antibody testing using cells expressing …

More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with
autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 …

Zebrafish are now widely accepted as a valuable animal model for a number of different
central nervous system (CNS) diseases. They are suitable both for elucidating the origin of …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

Epilepsy is a devastating and poorly understood disease. Mutations in a secreted neuronal
protein, leucine-rich glioma inactivated 1 (LGI1), were reported in patients with an inherited …

Potassium (K+) channels are expressed in almost every cells and are ubiquitous in neuronal
and glial cell membranes. These channels have been implicated in different disorders, in …

Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic epilepsy syndrome
clinically characterized by focal seizures with prominent auditory symptoms. ADLTE is …

One quadrillion synapses are laid in the first two years of postnatal construction of the
human brain, which are then pruned until age 10 to 500 trillion synapses composing the …