Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023 - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

[HTML][HTML] The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes

V Sencio, MG Machado, F Trottein - Mucosal Immunology, 2021 - Elsevier
Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut
microbiota has a critical role in pulmonary immunity and host's defense against viral …

[HTML][HTML] Mechanism of the gut microbiota colonization resistance and enteric pathogen infection

I Khan, Y Bai, L Zha, N Ullah, H Ullah… - Frontiers in Cellular …, 2021 - frontiersin.org
The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

Gut microbiota and colonization resistance against bacterial enteric infection

QR Ducarmon, RD Zwittink, BVH Hornung… - Microbiology and …, 2019 - Am Soc Microbiol
The gut microbiome is critical in providing resistance against colonization by exogenous
microorganisms. The mechanisms via which the gut microbiota provide colonization …

[HTML][HTML] Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

J Chu, S Feng, C Guo, B Xue, K He, L Li - Biomedicine & …, 2023 - Elsevier
The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

The role of the microbiota in infectious diseases

J Libertucci, VB Young - Nature microbiology, 2019 - nature.com
The human body is colonized by a diverse community of microorganisms collectively
referred to as the microbiota. Here, we describe how the human microbiota influences …

Biological function of short-chain fatty acids and its regulation on intestinal health of poultry

L Liu, Q Li, Y Yang, A Guo - Frontiers in Veterinary Science, 2021 - frontiersin.org
Short-chain fatty acids (SCFAs) are metabolites generated by bacterial fermentation of
dietary fiber (DF) in the hindgut. SCFAs are mainly composed of acetate, propionate and …