Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

The Hippo‐YAP pathway regulates organ size, tissue homeostasis, and tumorigenesis in
mammals. In response to cell density, external mechanical pressure, and/or other stimuli, the …

Abstract Three-dimensional (3D) organoids are a novel tool to model epithelial cell biology
and human diseases of the esophagus. 3D organoid culture systems have been utilized to …

Abstract Trachea-esophageal defects (TEDs), including esophageal atresia (EA),
tracheoesophageal fistula (TEF), and laryngeal-tracheoesophageal clefts (LTEC), are a …

The esophagus and stomach, joined by a unique transitional zone, contain actively dividing
epithelial stem cells required for organ homeostasis. Upon prolonged inflammation …

The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface
between the esophagus and stomach, with significant relevance in the pathophysiology of …

The esophagus is derived from the anterior portion of the foregut endoderm, which also
gives rise to the respiratory system. As it develops, the esophageal lining is transformed from …

The gastrointestinal system is a hollow organ affected by fibrostenotic diseases that cause
volumetric compromise of the lumen via smooth muscle hypertrophy and fibrosis. Many of …

Organoids constitute biological systems which are used to model organ development,
homeostasis, regeneration, and disease in vitro and hold promise for use in therapy …