A-to-I RNA editing—immune protector and transcriptome diversifier
E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …
Novel insights into double-stranded RNA-mediated immunopathology
R de Reuver, J Maelfait - Nature Reviews Immunology, 2024 - nature.com
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
ADAR1 mutation causes ZBP1-dependent immunopathology
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
Long 3′ UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …
Human ADAR1 prevents endogenous RNA from triggering translational shutdown
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …
Translation inhibition and stress granules in the antiviral immune response
C McCormick, DA Khaperskyy - Nature Reviews Immunology, 2017 - nature.com
Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …
rapidly reprioritize the translation machinery in response to varied environmental assaults …
The competitive landscape of the dsRNA world
KA Cottrell, RJ Andrews, BL Bass - Molecular Cell, 2024 - cell.com
The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation
Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …