Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …

Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …