Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as
a target for the activity of antifungals, have been known for decades. Two recent studies …

Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

There has been considerable evidence in recent years suggesting that plasma membrane
lipids are important regulators of fungal pathogenicity. Various glycolipids have been shown …

Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …

Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years,
work in this field has revealed more information about fungal EVs. Fungal EVs have been …

Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal
meningoencephalitis in immunocompromised individuals and is responsible for a large …

Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …