[HTML][HTML] Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics

S Dai, C Wang, XT Zhao, C Ma, K Fu, Y Liu… - Pharmacological …, 2023 - Elsevier
Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Cucurbitacins and cucurbitane glycosides: structures and biological activities

JC Chen, MH Chiu, RL Nie, GA Cordell… - Natural product reports, 2005 - pubs.rsc.org
Covering: 1980 to August 2004 The natural cucurbitacins constitute a group of triterpenoid
substances which are well-known for their bitterness and toxicity. Structurally, they are …

Phytochemicals from plants to combat cardiovascular disease

HR Vasanthi, N ShriShriMal… - Current medicinal …, 2012 - ingentaconnect.com
For many decades, the use of synthetic chemicals as drugs has been effective in the
treatment of most diseases. Moreover, from ancient to modern history, many traditional plant …

Ethnopharmacological survey of medicinal herbs in Jordan, the Ajloun Heights region

T Aburjai, M Hudaib, R Tayyem, M Yousef… - Journal of …, 2007 - Elsevier
The study of local knowledge about natural resources is becoming increasingly important in
defining strategies and actions for conservation of medicinal plants. This study therefore …

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

KT Chan, FY Meng, Q Li, CY Ho, TS Lam, Y To… - Cancer letters, 2010 - Elsevier
Cucurbitacin B is an anti-cancer drug candidate and its efficacy has been demonstrated in
hepatocellular carcinoma (HCC). To explore its mechanism against HCC, BEL-7402 cells …

Chromatographic procedures for the isolation of plant steroids

L Dinan, J Harmatha, R Lafont - Journal of chromatography A, 2001 - Elsevier
In this review, we consider the general principles and specific methods for the purification of
different classes of phytosteroids which have been isolated from plant sources …

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

KT Chan, K Li, SL Liu, KH Chu, M Toh, WD Xie - Cancer letters, 2010 - Elsevier
Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-
cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining …

Hepatoprotective natural triterpenoids

GB Xu, YH Xiao, QY Zhang, M Zhou, SG Liao - European journal of …, 2018 - Elsevier
Liver diseases are one of the leading causes of death in the world. In spite of tremendous
advances in modern drug research, effective and safe hepatoprotective agents are still in …

Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo

N Wakimoto, D Yin, J O'Kelly, T Haritunians… - Cancer …, 2008 - Wiley Online Library
Cucurbitacins are a group of diverse triterpenoid substances isolated from plants with
medicinal properties. One particularly potent family member is cucurbitacin B (CuB). The …

[PDF][PDF] Search for a novel antioxidant, anti-inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace

SA Bernard, OA Olayinka - J Med Plants Res, 2010 - academicjournals.org
Cucurbitacins are triterpenoid steroids reported to have several biological activities and are
predominantly isolated from Cucurbitaceae family. They are efficient anti-oxidant and this …