To cite this article: Aalberse RC, Crameri R. IgE‐binding epitopes: a reappraisal. Allergy
2011; 66: 1261–1274. Abstract Here, we discuss various questions related to IgE epitopes …

The best-understood mechanisms for achieving antibody self/non-self discrimination discard
self-reactive antibodies before they can be tested for binding microbial antigens, potentially …

Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it
remains unclear how such specificity is acquired. In a mouse model, we generated B cells …

We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …

Isothermal titration calorimetry (ITC) is now an established and invaluable method for
determining the thermodynamic constants, association constant and stoichiometry of …

Monoclonal antibodies have become an important class of therapeutics in the last 30 years.
Because the mechanism of action of therapeutic antibodies is intimately linked to their …

Human high-affinity antibodies to pathogens often recognize unrelated ligands. The
molecular origin and the role of this polyreactivity are largely unknown. Here, we report that …

Conformational diversity and self-cross-reactivity of antigens have been correlated with
evasion from neutralizing antibody responses. We utilized single cell B cell sequencing …

High-resolution structures of liganded and unliganded antibody molecules were analyzed in
terms of the interaction between the antibody with ligand, between the residues in the …

Antibodies (immunoglobulins) bind specific molecules (ie antigens) with high affinity and
specificity. In order to understand their mechanisms of recognition, interaction analysis …