From mesenchymal stromal/stem cells to insulin-producing cells: progress and challenges

MA Ghoneim, AF Refaie, BL Elbassiouny… - Stem Cell Reviews and …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are an attractive option for cell therapy for type 1
diabetes mellitus (DM). These cells can be obtained from many sources, but bone marrow …

Current status of stem cell therapy for type 1 diabetes: a critique and a prospective consideration

MA Ghoneim, MM Gabr, SM El-Halawani… - Stem Cell Research & …, 2024 - Springer
Over the past decade, there had been progress in the development of cell therapy for insulin-
dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain …

[HTML][HTML] Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

XF Lian, DH Lu, HL Liu, YJ Liu, XQ Han… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Progressive pancreatic β-cell dysfunction is a fundamental part of the
pathology of type 2 diabetes mellitus (T2DM). Cellular therapies offer novel opportunities for …

Mesenchymal stem cell therapy in diabetic cardiomyopathy

JS da Silva, RGJ Gonçalves, JF Vasques, BS Rocha… - Cells, 2022 - mdpi.com
The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, and the
resulting cardiac complications are the leading cause of death. Among these complications …

Mesenchymal stem cells: an excellent candidate for the treatment of diabetes mellitus

Q Huang, Y Huang, J Liu - International Journal of …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult stem cells (ASCs) known for repairing damaged
cells, exerting anti‐inflammatory responses and producing immunoregulatory effects that …

Efficacy of mesenchymal stem cell therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta‐analysis

H Ranjbaran, B Mohammadi Jobani… - Journal of Diabetes …, 2021 - Wiley Online Library
Abstract Aims/Introduction In recent years, mesenchymal cellular therapies have received
much attention in the treatment of diabetes. In this meta‐analysis, we aimed to evaluate the …

Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

M Khazaei, F Khazaei, E Niromand… - Journal of drug …, 2023 - Taylor & Francis
Tissue engineering (TE) has become a new effective solution to a variety of medical
problems, including diabetes. Mesenchymal stem cells (MSCs), which have the ability to …

Application of mesenchymal stem cells derived from the umbilical cord or Wharton's jelly and their extracellular vesicles in the treatment of various diseases

AA Patel, HM Asma'a, J Rizaev, AK Mallick, MT Qasim… - Tissue and Cell, 2024 - Elsevier
Mesenchymal stem cells (MSCs) originating from the umbilical cord (UC) or Wharton's jelly
(WJ) have attracted substantial interest due to their potential to augment therapeutic …

Autophagy enhances the differentiation of insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells

N Azarbarz, F Nejaddehbashi, L Khorsandi, DB Nejad… - Tissue and Cell, 2024 - Elsevier
Autophagy disruption suppresses insulin production and induces diabetes. The role of
autophagy in the differentiation of Wharton's jelly (WJ)-derived mesenchymal stem cells …

Perinatal Stem Cell Therapy to Treat Type 1 Diabetes Mellitus: A Never-Say-Die Story of Differentiation and Immunomodulation

F Paris, V Pizzuti, P Marrazzo, A Pession… - International Journal of …, 2022 - mdpi.com
Human term placenta and other postpartum-derived biological tissues are promising
sources of perinatal cells with unique stem cell properties. Among the massive current …