It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

Nanoparticle-sensitized photoporation is an upcoming approach for the intracellular delivery
of biologics, combining high efficiency and throughput with excellent cell viability. However …

The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …

Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined
factors, hold great promise for regenerative medicine as the renewable source of autologous …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent
stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques …

Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a
powerful tool for biomedical research and may provide a source for replacement therapies …

To identify cell-surface markers specific to human cardiomyocytes, we screened
cardiovascular cell populations derived from human embryonic stem cells (hESCs) against a …

NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-
5 locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …