The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery
NA di Meo, F Lasorsa, M Rutigliano… - Expert Review of …, 2023 - Taylor & Francis
Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …
macromolecules involved in a wide range of metabolic pathways. The increased …
Challenges for clinical drug development in pulmonary fibrosis
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …
PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
S Peng, Z Wang, P Tang, S Wang, Y Huang, Q Xie… - Science …, 2023 - science.org
For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the
development, metastasis, and drug resistance. However, the molecular mechanisms …
development, metastasis, and drug resistance. However, the molecular mechanisms …
The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling
J Shi, D Miao, Q Lv, K Wang, Q Wang, H Liang… - Cell Death & …, 2023 - nature.com
Metabolic reprogramming is a hallmark of cancer, and the impact of lipid metabolism as a
crucial aspect of metabolic reprogramming on clear cell renal cell carcinoma (ccRCC) …
crucial aspect of metabolic reprogramming on clear cell renal cell carcinoma (ccRCC) …
PI3K/AKT/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: Crosstalk with the VHL/HIF axis
Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
Metabolic reprogramming of clear cell renal cell carcinoma
H Zhu, X Wang, S Lu, K Ou - Frontiers in endocrinology, 2023 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is a malignancy that exhibits metabolic
reprogramming as a result of genetic mutations. This reprogramming accommodates the …
reprogramming as a result of genetic mutations. This reprogramming accommodates the …
LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers
As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been
becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is …
becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is …
Fatty acid desaturase 1 (FADS1) is a cancer marker for patient survival and a potential novel target for precision cancer treatment
G Heravi, H Jang, X Wang, Z Long, Z Peng… - Frontiers in …, 2022 - frontiersin.org
Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme
involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), ie …
involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), ie …
Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics
Y Wang, X Liu, L Gong, W Ding, W Hao… - British Journal of …, 2023 - Wiley Online Library
Sunitinib is the first‐line drug for renal cell carcinoma (RCC) treatment. However, patients
who received sunitinib treatment will ultimately develop drug resistance after 6–15 months …
who received sunitinib treatment will ultimately develop drug resistance after 6–15 months …
ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma
L Zhen, W Pan - Clinical and Experimental Pharmacology and …, 2023 - Wiley Online Library
Cervical cancer (CC) is the most common malignancy of the female reproductive system,
among which cervical squamous cell carcinoma (CESC) is the most common type. The …
among which cervical squamous cell carcinoma (CESC) is the most common type. The …