The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery

NA di Meo, F Lasorsa, M Rutigliano… - Expert Review of …, 2023 - Taylor & Francis
Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Challenges for clinical drug development in pulmonary fibrosis

ES White, M Thomas, S Stowasser… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

S Peng, Z Wang, P Tang, S Wang, Y Huang, Q Xie… - Science …, 2023 - science.org
For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the
development, metastasis, and drug resistance. However, the molecular mechanisms …

The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling

J Shi, D Miao, Q Lv, K Wang, Q Wang, H Liang… - Cell Death & …, 2023 - nature.com
Metabolic reprogramming is a hallmark of cancer, and the impact of lipid metabolism as a
crucial aspect of metabolic reprogramming on clear cell renal cell carcinoma (ccRCC) …

PI3K/AKT/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: Crosstalk with the VHL/HIF axis

SC Badoiu, M Greabu, D Miricescu… - International journal of …, 2023 - mdpi.com
Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …

Metabolic reprogramming of clear cell renal cell carcinoma

H Zhu, X Wang, S Lu, K Ou - Frontiers in endocrinology, 2023 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is a malignancy that exhibits metabolic
reprogramming as a result of genetic mutations. This reprogramming accommodates the …

LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers

S Liu, B Jiao, H Zhao, X Liang, F Jin, X Liu… - Advanced …, 2024 - Wiley Online Library
As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been
becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is …

Fatty acid desaturase 1 (FADS1) is a cancer marker for patient survival and a potential novel target for precision cancer treatment

G Heravi, H Jang, X Wang, Z Long, Z Peng… - Frontiers in …, 2022 - frontiersin.org
Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme
involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), ie …

Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics

Y Wang, X Liu, L Gong, W Ding, W Hao… - British Journal of …, 2023 - Wiley Online Library
Sunitinib is the first‐line drug for renal cell carcinoma (RCC) treatment. However, patients
who received sunitinib treatment will ultimately develop drug resistance after 6–15 months …

ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma

L Zhen, W Pan - Clinical and Experimental Pharmacology and …, 2023 - Wiley Online Library
Cervical cancer (CC) is the most common malignancy of the female reproductive system,
among which cervical squamous cell carcinoma (CESC) is the most common type. The …