Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …

The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …

The kinase mTOR has emerged as an important regulator of the differentiation of helper T
cells. Here we demonstrate that differentiation into the TH1 and TH17 subsets of helper T …

Effector T cell differentiation requires the simultaneous integration of multiple, and
sometimes opposing, cytokine signals. We demonstrated mTOR's role in dictating the …

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

Asymmetric cell division, the partitioning of cellular components in response to polarizing
cues during mitosis, has roles in differentiation and development. It is important for the self …

Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy
requirements for this expansion are formidable, and T‐cell activation is accompanied by …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …