Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

With increasing number of immunocompromised patients as well as drug resistance in fungi,
the risk of fatal fungal infections in humans increases as well. The action of echinocandins is …

Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …

Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in
several cellular processes. The calcineurin signaling cascade is one of the major pathways …

Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However,
FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making …

Fungal pathogens use various mechanisms to survive exposure to drugs. Prolonged
treatment very often leads to the stepwise acquisition of resistance. The limited number of …

Candidiasis has increased significantly recently that threatens patients with low immunity.
However, the number of antifungal drugs on the market is limited in comparison to the …

Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of
cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in …

Silkworm, Bombyx mori, has various advantages as an experimental animal, such as the low
cost for rearing and fewer ethical problems. Models utilizing silkworms of infection with …