Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Short-term synaptic plasticity
▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
In Alzheimer's disease (AD), dementia severity correlates strongly with decreased synapse
density in hippocampus and cortex. Numerous studies report that hippocampal long-term …
density in hippocampus and cortex. Numerous studies report that hippocampal long-term …
[PDF][PDF] Structure, function, and pharmacology of NMDA receptor channels
V Vyklicky, M Korinek, T Smejkalova, A Balik… - Physiological …, 2014 - researchgate.net
Structure, Function, and Pharmacology of NMDA Receptor Channels Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …
D-serine added to antipsychotics for the treatment of schizophrenia
Background: Hypofunction of N-methyl-D-aspartate (NMDA) subtype glutamate receptor has
been implicated in the pathophysiology of schizophrenia. D-serine is a full agonist of the …
been implicated in the pathophysiology of schizophrenia. D-serine is a full agonist of the …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system
RA Nicoll, RC Malenka, JA Kauer - Physiological reviews, 1990 - journals.physiology.org
Communication between nerve cells in the central nervous system (CNS) occurs at
synapses, which are specialized sites between the presynaptic nerve terminal and the …
synapses, which are specialized sites between the presynaptic nerve terminal and the …
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit
NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel
activation. The glycine binding site of these heteromeric receptor proteins is formed by …
activation. The glycine binding site of these heteromeric receptor proteins is formed by …
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
EK Michaelis - Progress in neurobiology, 1998 - Elsevier
Forty years of research into the function of l-glutamic acid as a neurotransmitter in the
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …