Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by
blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin …

Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has
been an active area of investigation over the past 20 years. The landmark discovery of …

In this short review we have tried to focus on some new relevant aspects of the
pharmacological control of inflammation. The clinical availability of new drugs able to …

Objective: The inflammatory component of most human inflammatory chronic diseases
implicates the production of proinflammatory cytokines. Tumor necrosis factor α (TNFα) and …

Dual inhibitors that block both cyclooxygenase (COX) and lipoxygenase (LOX) metabolic
pathways of arachidonic acid are expected to possess clinical advantages over the selective …

Inflammation is associated with the development of several diseases comprising cancer and
cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase …

The objective of this study is to assess the effectiveness of treatment for inflammatory bowel
diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review …

Management of Inflammatory Bowel Disease | AAFP Advertisement search close brand logo
V. ALIN BOTOMAN, MD, GREGORY F. BONNER, MD, AND DANIELA A. BOTOMAN, MD Am …

Cytokines, particularly the proinfiammatory cytokines, whose role and natural regulation in
inflammatory bowel disease are reviewed here, are produced by many cell types, including …