Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

The liver can regenerate its volume after major tissue loss. In a mouse model of liver
regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate …

Interruption of blood flow to an organ or tissue (ischemia) and subsequent reperfusion lead
to an acute inflammatory response that may cause significant cellular damage and organ …

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …