Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …

Recent milestones in the understanding of gastric acid secretion and treatment of acid-
peptic disorders include the (1) discovery of histamine H2-receptors and development of …

Thirty years ago, disorders associated with inappropriate levels of gastric acid were a major
problem for which treatment options were limited, and approaches to the control of gastric …

Proton pump inhibitors inhibit the gastric H+/K+‐ATPase via covalent binding to cysteine
residues of the proton pump. All proton pump inhibitors must undergo acid accumulation in …

The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive
oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive …

Аннотация Цель представления клинических рекомендаций, предназначенных для
врачей-гастроэнтерологов, врачей общей практики (семейных врачей), врачей …

One of the hallmarks of the mammalian stomach is its ability to secrete large quantities of
concentrated (0.16 mol/L) hydrochloric acid (HCl). 1 Although it is generally assumed that …

Aim Comparative potency of proton-pump inhibitors (PPIs) is an important clinical issue.
Most available trials have compared the different PPIs at one or a few selected specific …

The mechanism of the antiulcer effect of omeprazole was studied placing emphasis on its
role to block oxidative damage and apoptosis during ulceration. Dose-response studies on …

ABSTRACT The gastric H+, K+ ATPase-the gastric acid pump-is the molecular target for the
class of antisecretory drugs called the proton-pump inhibitors (PPls). These compounds …