Locus coeruleus: a new look at the blue spot
The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …
Predictive processing: a canonical cortical computation
GB Keller, TD Mrsic-Flogel - Neuron, 2018 - cell.com
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …
understanding cortical function in the context of emerging evidence, with a focus on sensory …
Fast-specific fluorescent probes to visualize norepinephrine signaling pathways and its flux in the epileptic mice brain
H Yan, Y Wang, F Huo, C Yin - Journal of the American Chemical …, 2023 - ACS Publications
Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …
Spatiotemporal dynamics of noradrenaline during learned behaviour
Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator,,–that
has been linked to multiple functions including arousal,,–, action and sensory gain,–, and …
has been linked to multiple functions including arousal,,–, action and sensory gain,–, and …
Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex
Rapid variations in cortical state during wakefulness have a strong influence on neural and
behavioural responses and are tightly coupled to changes in pupil size across species …
behavioural responses and are tightly coupled to changes in pupil size across species …
Balancing exploration and exploitation with information and randomization
Explore-exploit decisions require us to trade off the benefits of exploring unknown options to
learn more about them, with exploiting known options, for immediate reward. Such decisions …
learn more about them, with exploiting known options, for immediate reward. Such decisions …
Adults with autism overestimate the volatility of the sensory environment
Insistence on sameness and intolerance of change are among the diagnostic criteria for
autism spectrum disorder (ASD), but little research has addressed how people with ASD …
autism spectrum disorder (ASD), but little research has addressed how people with ASD …
Waking state: rapid variations modulate neural and behavioral responses
The state of the brain and body constantly varies on rapid and slow timescales. These
variations contribute to the apparent noisiness of sensory responses at both the neural and …
variations contribute to the apparent noisiness of sensory responses at both the neural and …
Active control of arousal by a locus coeruleus GABAergic circuit
V Breton-Provencher, M Sur - Nature neuroscience, 2019 - nature.com
Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition.
However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we …
However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we …
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …
processing of other information. Here, we propose that, under arousal, local glutamate levels …