Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling
as a mechanism of human systemic autoimmune disease,,,,,–, evidence of lupus-causing …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Introduction Loss-of-function TLR7 variants have been recently reported in a small number
of males to underlie strong predisposition to severe COVID-19. We aimed to determine the …

Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …

The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

It has been found that the majority of disease-associated genetic variants identified by
genome-wide association studies are located outside of protein-coding regions, where they …

Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR)
and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B …