The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Abstract 4D printing refers to single-material or multi-material printing of a device or object
that can be transformed from a 1D strand into pre-programed 3D shape, from a 2D surface …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV
APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with …

Crystal Engineering has traditionally dealt with molecular crystals. It is the understanding of
intermolecular interactions in the context of crystal packing and in the utilization of such …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Crystallization is one of the oldest separation and purification unit operations, and has
recently contributed to significant improvements in producing higher-value products with …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …