Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins,
calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the …

Over the past decade, an enormous number of studies (> 100) have focused on the role of
nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in …

Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S) together make up a
family of biologically active gases (the so-called 'gaseous triumvirate') with an increasingly …

Ischemic preconditioning renders the heart resistant to infarction from ischemia/reperfusion.
Over the past two decades a great deal has been learned about preconditioning's …

Bradykinin (BK) mimics ischemic preconditioning by generating reactive oxygen species
(ROS). To identify intermediate steps that lead to ROS generation, rabbit cardiomyocytes …

1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …

AIM: Dexmedetomidine is a highly specific and selective α-2 adrenergic agonist that is now
widely used in the intensive care setting. Many intensive care unit (ICU) patients are at risk …

Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In
addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate …

Reactive oxygen species (ROS) and nitric oxide (NO) are implicated in induction of ischemic
preconditioning. However, the relationship between these oxidant signals and opening of …