Precursor message RNA requires processing to generate mature RNA. Cleavage and
polyadenylation at the 3′-end in the maturation of mRNA is one of key processing steps in …

Comprehending the molecular basis of quantitative genetic variation is a principal goal for
complex diseases or traits. Molecular quantitative trait loci (molQTLs) have made it possible …

The broadly used 10X Genomics technology for single-cell RNA sequencing (scRNA-seq)
captures RNA 3′ ends. Thus, some reads contain part of the non-templated polyadenosine …

During the past few years, unexpected developments have driven studies in the field of
clinical immunology. One driver of immense impact was the outbreak of a pandemic caused …

Genetic mutations arising from various internal and external factors drive cells to become
cancerous. Cancerous cells undergo numerous changes, including metabolic …

Intronic polyadenylation (IPA) is an RNA 3'end processing event which has been reported to
play important roles in cancer development. However, the comprehensive landscape of IPA …

Aims This study aims to reveal transcriptome-wide intronic polyadenylation (IPA) events
associated with Pre-eclampsia (PE). Background Pre-eclampsia (PE) is a potentially life …

可变多聚腺苷酸化(Alternative Polyadenylation, APA) 作为一种转录后调控机制,
其在基因表达调控中的作用越来越受到重视. 近期的许多研究发现APA 在肿瘤的发生发展和耐 …

This thesis widens our knowledge of key aspects of genomics approaches that can be
implemented in the study of ischemic stroke. The main objective of the present thesis …

Although rare non-coding variants (RVs) play crucial roles in human complex traits and
diseases, understanding their functional mechanisms and identifying those most closely …