Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …

Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …

Our understanding of the molecular events driving cell specification in early mammalian
development relies mainly on mouse studies, and it remains unclear whether these …

STUDY QUESTION Which processes and transcription factors specify the first and second
lineage segregation events during human preimplantation development? SUMMARY …

Successful human pregnancy depends upon rapid establishment of three founder lineages:
the trophectoderm, epiblast and hypoblast, which together form the blastocyst. Each plays …

Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in
the body can be traced to the 2-cell stage embryo. However, whether and how such clonal …

Development is a complex process that occurs throughout the life cycle. F-actin, a major
component of the cytoskeleton, is essential for the morphogenesis of tissues and organs …