IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
K Taniguchi, M Karin - Seminars in immunology, 2014 - Elsevier
Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …
promotion, progression, and metastasis. Cytokines are now recognized as important …
Ribosomal protein S6: a potential therapeutic target against cancer?
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
Profiling of discrete gynecological cancers reveals novel transcriptional modules and common features shared by other cancer types and embryonic stem cells
Studies on individual types of gynecological cancers (GCs), utilizing novel expression
technologies, have revealed specific pathogenetic patterns and gene markers for cervical …
technologies, have revealed specific pathogenetic patterns and gene markers for cervical …
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma
Proinflammatory cytokines are frequently observed in the tumor microenvironment, and
chronic inflammation is involved in cancer initiation and progression. We show that cytokine …
chronic inflammation is involved in cancer initiation and progression. We show that cytokine …
Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
The enigmatic cytokine oncostatin m and roles in disease
CD Richards - International Scholarly Research Notices, 2013 - Wiley Online Library
Oncostatin M is a secreted cytokine involved in homeostasis and in diseases involving
chronic inflammation. It is a member of the gp130 family of cytokines that have pleiotropic …
chronic inflammation. It is a member of the gp130 family of cytokines that have pleiotropic …
Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets
Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors
(GCT) are thought to originate from primordial germ cells. However, no common biological …
(GCT) are thought to originate from primordial germ cells. However, no common biological …
Cancer stem cell plasticity drives therapeutic resistance
MR Doherty, JM Smigiel, DJ Junk, MW Jackson - Cancers, 2016 - mdpi.com
The connection between epithelial-mesenchymal (EM) plasticity and cancer stem cell (CSC)
properties has been paradigm-shifting, linking tumor cell invasion and metastasis with …
properties has been paradigm-shifting, linking tumor cell invasion and metastasis with …
The clinical relevance of OSM in inflammatory diseases: a comprehensive review
CL Wolf, C Pruett, D Lighter, CL Jorcyk - Frontiers in Immunology, 2023 - frontiersin.org
Oncostatin M (OSM) is a pleiotropic cytokine involved in a variety of inflammatory responses
such as wound healing, liver regeneration, and bone remodeling. As a member of the …
such as wound healing, liver regeneration, and bone remodeling. As a member of the …
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in …
Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is
upregulated in various human cancers, including colorectal cancer (CRC). This study …
upregulated in various human cancers, including colorectal cancer (CRC). This study …