Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Two faces of vitamin C—antioxidative and pro-oxidative agent

J Kaźmierczak-Barańska, K Boguszewska… - Nutrients, 2020 - mdpi.com
Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …

Strawberry-derived exosome-like nanoparticles prevent oxidative stress in human mesenchymal stromal cells

F Perut, L Roncuzzi, S Avnet, A Massa, N Zini… - Biomolecules, 2021 - mdpi.com
Plant-derived exosome-like nanovesicles (EPDENs) have recently been isolated and
evaluated as potential bioactive nutraceutical biomolecules. It has been hypothesized that …

Vitamin C in plants: from functions to biofortification

C Paciolla, S Fortunato, N Dipierro, A Paradiso… - Antioxidants, 2019 - mdpi.com
Vitamin C (l-ascorbic acid) is an excellent free radical scavenger, not only for its capability to
donate reducing equivalents but also for the relative stability of the derived …

Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue

C Vollbracht, K Kraft - Nutrients, 2021 - mdpi.com
Fatigue is common not only in cancer patients but also after viral and other infections.
Effective treatment options are still very rare. Therefore, the present knowledge on the …

Pathways of Gastric Carcinogenesis, Helicobacter pylori Virulence and Interactions with Antioxidant Systems, Vitamin C and Phytochemicals

JWT Toh, RB Wilson - International journal of molecular sciences, 2020 - mdpi.com
Helicobacter pylori is a class one carcinogen which causes chronic atrophic gastritis, gastric
intestinal metaplasia, dysplasia and adenocarcinoma. The mechanisms by which H. pylori …

Regulation of vitamin C accumulation for improved tomato fruit quality and alleviation of abiotic stress

I Mellidou, A Koukounaras, S Kostas, E Patelou… - Genes, 2021 - mdpi.com
Ascorbic acid (AsA) is an essential multifaceted phytonutrient for both the human diet and
plant growth. Optimum levels of AsA accumulation combined with balanced redox …

Medicinal prospects of antioxidants from algal sources in cancer therapy

UT Ferdous, ZNB Yusof - Frontiers in Pharmacology, 2021 - frontiersin.org
Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of
these medications is mostly restricted to several deleterious side effects. Therefore, to …

Therapeutic perspective of vitamin C and its derivatives

A Meščić Macan, T Gazivoda Kraljević, S Raić-Malić - Antioxidants, 2019 - mdpi.com
l-Ascorbic acid (ASA), vitamin C, is a ubiquitous carbohydrate-like compound that has an
essential role in a number of cellular processes, such as collagen synthesis, cellular …

[HTML][HTML] Role of Micronutrients and Nutrition in Prevention and Treatment of Cancers

F Taheri, M Farrokhi, AM Fard, E Rahmani, R Soltani… - Kindle, 2023 - preferpub.org
Cancer is a complex disease that affects millions of people worldwide. While genetics and
lifestyle factors play a significant role in cancer development, the role of diet and …