Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

Spike protein mediated membrane fusion during SARS‐CoV‐2 infection

X Li, H Yuan, X Li, H Wang - Journal of Medical Virology, 2023 - Wiley Online Library
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has posed a serious threat to public health and has quickly become a global concern. The …

Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization

L Di Filippo, M Uygur, M Locatelli, F Nannipieri, S Frara… - Endocrine, 2023 - Springer
Purpose Low vitamin D in COVID-19 have been related to worse outcomes. However, most
of the studies conducted so far were not-controlled and retrospective, including biases …

ACE2 Shedding and the Role in COVID-19

J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions

SM Christie, T Tada, Y Yin, A Bhardwaj, NR Landau… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health
crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral …

SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells

L Miao, C Yan, Y Chen, W Zhou, X Zhou, Q Qiao… - Cell chemical …, 2023 - cell.com
It is urgent to understand the infection mechanism of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) for the prevention and treatment of COVID-19. The infection of …

Facilitating and restraining virus infection using cell-attachable soluble viral receptors

H Zhang, Z Wang, HTT Nguyen… - Proceedings of the …, 2024 - pnas.org
SARS-CoV-2 uses the receptor binding domain (RBD) of its spike protein to recognize and
infect host cells by binding to the cell surface receptor angiotensin converting enzyme 2 …

Low-Density Lipoprotein Receptor (LDLR) is involved in internalization of lentiviral particles pseudotyped with SARS-CoV-2 spike protein in ocular cells

S Uppal, O Postnikova, R Villasmil, IB Rogozin… - International Journal of …, 2023 - mdpi.com
Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway
for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19. Firstly, we found that …

S protein, ACE2 and host cell proteases in SARS-CoV-2 cell entry and infectivity; is soluble ACE2 a two blade sword? A narrative review

R Nejat, MF Torshizi, DJ Najafi - Vaccines, 2023 - mdpi.com
Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …

Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections

S Mani, A Kaur, K Jakhar, G Kumari, S Sonar… - International Journal of …, 2023 - Elsevier
Highly mutated SARS-CoV-2 is known aetiological factor for COVID-19. Here, we have
demonstrated that the receptor binding domain (RBD) of the spike protein can interact with …