Unlocking trophectoderm mysteries: In vivo and in vitro perspectives on human and mouse trophoblast fate induction
M Azagury, Y Buganim - Developmental Cell, 2024 - cell.com
In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …
prominence as a compelling research objective, illuminating the establishment of the …
Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity
A Radwan, J Eccleston, O Sabag, H Marcus… - Proceedings of the …, 2024 - pnas.org
A number of studies have demonstrated that it is possible to directly convert one cell type to
another by factor-mediated transdifferentiation, but in the vast majority of cases, the resulting …
another by factor-mediated transdifferentiation, but in the vast majority of cases, the resulting …
Pluripotency-independent induction of human trophoblast stem cells from fibroblasts
M Naama, M Rahamim, V Zayat, S Sebban… - Nature …, 2023 - nature.com
Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or
be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore …
be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore …
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects
R Lasry, N Maoz, AW Cheng, NY Tov, E Kulenkampff… - Stem cell reports, 2023 - cell.com
A complete knockout of a single key pluripotency gene may drastically affect embryonic stem
cell function and epigenetic reprogramming. In contrast, elimination of only one allele of a …
cell function and epigenetic reprogramming. In contrast, elimination of only one allele of a …
Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency
N Bekas, M Samiotaki, M Papathanasiou, P Mokos… - Cancers, 2023 - mdpi.com
Simple Summary Many aspects of the regulatory mechanisms of somatic cell
reprogramming—the conversion of any cell type into pluripotent stem cells—still remain …
reprogramming—the conversion of any cell type into pluripotent stem cells—still remain …
Derivation of trophoblast stem cells unveils unrestrained potential of mouse ESCs and epiblast
SUMMARY mESCs and epiblast are considered to follow strict lineage adherence and lack
the potential to contribute to trophoectoderm. Here, we report the derivation of trophoblast …
the potential to contribute to trophoectoderm. Here, we report the derivation of trophoblast …
Derivation of trophoblast stem cells unveils unrestrained potential of mouse embryonic stem cells and epiblast
D Jana, P Singh, P Sailasree, M Srivastava, N Kumar… - 2023 - researchsquare.com
Mouse epiblast and embryonic stem cells (mESCs) are considered to adhere strict lineage
restriction and lack the potential to contribute to trophoectoderm (TE). In contrast, here we …
restriction and lack the potential to contribute to trophoectoderm (TE). In contrast, here we …