Methods and products for analyzing polymers

EY Chan - US Patent 8,168,380, 2012 - Google Patents
US8168380B2 - Methods and products for analyzing polymers - Google Patents
US8168380B2 - Methods and products for analyzing polymers - Google Patents Methods and …

Molecular and atomic scale evaluation of biopolymers

D Branton, JA Golovchenko, TJ Denison - US Patent 6,627,067, 2003 - Google Patents
(57) ABSTRACT A method for evaluating a polymer molecule including linearly connected
monomer residues includes providing a polymer molecule in a liquid, contacting the liquid …

Methods and apparatus for characterizing polynucleotides

M Akeson, D Branton, DW Deamer… - US Patent …, 2007 - Google Patents
Abstract Systems and methods for analysis of polymers, eg, polynucleotides, are provided.
The systems are capable of analyzing a polymer at a specified rate. One such analysis …

Nanochannel arrays and their preparation and use for high throughput macromolecular analysis

SY Chou, H Cao, RH Austin, Z Yu… - US Patent …, 2010 - Google Patents
Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed.
Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips …

Characterization of individual polymer molecules based on monomer-interface interactions

M Akeson, D Branton, G Church… - US Patent 7,189,503, 2007 - Google Patents
The invention relates to a method for detecting a double-stranded region in a nucleic acid by
(1) providing two separate, adjacent pools of a medium and a interface between the two …

Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof

H Cao, JO Tegenfeldt, S Chou, RH Austin - US Patent 7,217,562, 2007 - Google Patents
The present invention relates to a device for interfacing nanofluidic and microfluidic
components suitable for use in performing high throughput macromolecular analysis …

Assay methods using nicking endonucleases

JS Oliver - US Patent 8,715,933, 2014 - Google Patents
Assay methods and apparatus for the analysis of biopolymers are disclosed. The assays
employ nicking endonucleases to enable the generation of flaps on target biomolecules …

Study of polymer molecules and conformations with a nanopore

JA Golovchenko, J Li, D Stein, MH Gershow - US Patent 7,846,738, 2010 - Google Patents
The invention features methods for evaluating the conformation of a polymer, for example,
for determining the conformational distribution of a plurality of polymers and to detect …

Methods and apparatus for characterizing polynucleotides

M Akeson, D Branton, DW Deamer… - US Patent …, 2011 - Google Patents
Abstract Systems and methods for analysis of polymers, eg, polynucleotides, are provided.
The systems are capable of analyzing a polymer at a specified rate. One such analysis …

Methods for analyzing a nucleic acid

E Chan, E Nalefski - US Patent App. 10/435,399, 2003 - Google Patents
SUMMARY OF THE INVENTION 0006 The method and apparatus of the invention involves
direct linear analysis of Several kilobase lengths of DNA for the generation of haplotypes …