Deciphering cell–cell interactions and communication from gene expression
E Armingol, A Officer, O Harismendy… - Nature Reviews …, 2021 - nature.com
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …
connections between genes, which impedes discoveries in settings with limited data …
Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells
Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …
depending on the vessel and tissue in which they are located. Whereas these functional …
[HTML][HTML] Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Single-cell reconstruction of progression trajectory reveals intervention principles in pathological cardiac hypertrophy
Z Ren, P Yu, D Li, Z Li, Y Liao, Y Wang, B Zhou… - Circulation, 2020 - Am Heart Assoc
Background: Pressure overload–induced pathological cardiac hypertrophy is a common
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …