The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes,
since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe …

Interferons (IFN s) have been reported in vertebrates from fish to mammals. To date, two
types of IFN s, ie type I and type II IFN s have been reported in a range of fish species in …

Highlights•Zebrafish are a useful tool for screening new drugs for inflammation.•This teleost
shares several inflammatory mediators and receptors with mammals.•The real-time …

IFN-γ, as the sole member of mammalian type II IFN, is a multifunctional cytokine which
exerts its effects through two distinct IFN-γ receptors, IFNGR1 and IFNGR2. However, in …

Research in human tuberculosis (TB) is limited by the availability of human tissues from
patients, which is often altered by therapy and treatment. Thus, the use of animal models is a …

Interferon gamma (IFN-γ) is a T helper cell type 1 (Th1) cytokine that plays important roles in
almost all phases of immune and inflammatory responses. Although IFN-γ gene in large …

IFN-γ is one of the key cytokines involved in Th1 immune responses. It is produced mainly
by T cells and NK cells, which drive both innate and adaptive responses to promote …

Nile tilapia (Oreochromis niloticus) is a freshwater fish, which is extensively cultivated
worldwide and constitutes one of the model species for the study of fish immunology …

Interferon gamma (IFN-γ) is one of the key players in the immune system of vertebrates. The
evolution and properties of IFN-γ and its receptors in fish species are of special interest as …

In the present study, we identify three type I interferon (IFN) genes (Ad/As IFNe1-3) and a
type II IFN gene (Ad/AsIFNγ) from the Dabry's sturgeon (Acipenser dabryanus) and the …