Endothelial dysfunction and vascular disease–a 30th anniversary update
PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …
Vascular nitric oxide resistance in type 2 diabetes
Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …
Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway
MI Sonmez, A Shahzadi, C Kose, H Sonmez… - Frontiers in …, 2022 - frontiersin.org
Background: Diabetes mellitus leads to endothelial dysfunction and accumulation of oxygen
radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels. Thus, in …
radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels. Thus, in …
Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats
B Musicki, JL Hannan, G Lagoda, TJ Bivalacqua… - …, 2016 - Wiley Online Library
Men with type 2 diabetes mellitus (T2 DM) and erectile dysfunction (ED) have greater risk of
cardiovascular events than T2 DM men without ED, suggesting ED as a predictor of …
cardiovascular events than T2 DM men without ED, suggesting ED as a predictor of …
A free-choice high-fat, high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats
H Ahmed, JL Hannan, JW Apolzan… - American Journal …, 2019 - journals.physiology.org
The main objective of these studies was to characterize metabolic, body composition, and
cardiovascular responses to a free-choice high-fat, high-sucrose diet in female cycling and …
cardiovascular responses to a free-choice high-fat, high-sucrose diet in female cycling and …
Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up4A-Mediated Vascular Contraction
Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction.
Uridine adenosine tetraphosphate (Up4A), a novel dinucleotide substance, regulates …
Uridine adenosine tetraphosphate (Up4A), a novel dinucleotide substance, regulates …
Ex vivo model of human penile transplantation and rejection: implications for erectile tissue physiology
Background Penile transplantation is a potential treatment option for severe penile tissue
loss. Models of human penile rejection are lacking. Objective Evaluate effects of rejection …
loss. Models of human penile rejection are lacking. Objective Evaluate effects of rejection …
Factors influencing the soluble guanylate cyclase heme redox state in blood vessels
M Tawa, T Okamura - Vascular Pharmacology, 2022 - Elsevier
Soluble guanylate cyclase (sGC) plays an important role in maintaining vascular
homeostasis, as an acceptor for the biological messenger nitric oxide (NO). However, only …
homeostasis, as an acceptor for the biological messenger nitric oxide (NO). However, only …
Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries
M Tawa, T Okamura - Pharmacology Research & Perspectives, 2016 - Wiley Online Library
Coronary artery disease is associated with oxidative stress due to the excessive generation
of free radicals in the vascular wall. This study investigated the impact of tert‐butyl …
of free radicals in the vascular wall. This study investigated the impact of tert‐butyl …
Hypoxia/reoxygenation of rat renal arteries impairs vasorelaxation via modulation of endothelium-independent sGC/cGMP/PKG signaling
D Braun, C Zollbrecht, S Dietze, R Schubert… - Frontiers in …, 2018 - frontiersin.org
Ischemia/reperfusion injury holds a key position in many pathological conditions such as
acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized …
acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized …