The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …

Background: Diabetes mellitus leads to endothelial dysfunction and accumulation of oxygen
radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels. Thus, in …

Men with type 2 diabetes mellitus (T2 DM) and erectile dysfunction (ED) have greater risk of
cardiovascular events than T2 DM men without ED, suggesting ED as a predictor of …

The main objective of these studies was to characterize metabolic, body composition, and
cardiovascular responses to a free-choice high-fat, high-sucrose diet in female cycling and …

Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction.
Uridine adenosine tetraphosphate (Up4A), a novel dinucleotide substance, regulates …

Background Penile transplantation is a potential treatment option for severe penile tissue
loss. Models of human penile rejection are lacking. Objective Evaluate effects of rejection …

Soluble guanylate cyclase (sGC) plays an important role in maintaining vascular
homeostasis, as an acceptor for the biological messenger nitric oxide (NO). However, only …

Coronary artery disease is associated with oxidative stress due to the excessive generation
of free radicals in the vascular wall. This study investigated the impact of tert‐butyl …

Ischemia/reperfusion injury holds a key position in many pathological conditions such as
acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized …