Molecular mechanisms and physiological importance of circadian rhythms

A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

[HTML][HTML] Social jetlag and related risks for human health: a timely review

R Caliandro, AA Streng, LWM van Kerkhof… - Nutrients, 2021 - mdpi.com
The term social jetlag is used to describe the discrepancy between biological time,
determined by our internal body clock, and social times, mainly dictated by social obligations …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

[HTML][HTML] Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

[HTML][HTML] Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes

JP Etchegaray, R Mostoslavsky - Molecular cell, 2016 - cell.com
The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Molecular components of the Mammalian circadian clock

ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

[HTML][HTML] A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

F Kroll, GT Powell, M Ghosh, G Gestri, P Antinucci… - elife, 2021 - elifesciences.org
Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

Metabolism and the circadian clock converge

K Eckel-Mahan, P Sassone-Corsi - Physiological reviews, 2013 - journals.physiology.org
Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

[HTML][HTML] The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm

S Honma - The Journal of Physiological Sciences, 2018 - Springer
The circadian nature of physiology and behavior is regulated by a circadian clock that
generates intrinsic rhythms with a periodicity of approximately 24 h. The mammalian …

Physiology of circadian entrainment

DA Golombek, RE Rosenstein - Physiological reviews, 2010 - journals.physiology.org
Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …