Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Current studies on actin function primarily rely on cytoplasmic actin due to the absence of
cellular models specifically expressing nuclear actin. Here, cell models capable of …

The Ras association domain family protein1 isoform A (RASSF1A) is a well-known tumor-
suppressor protein frequently inactivated in various human cancers. Consistent with its …

The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate
extracellular stimuli that result in intracellular activities. Previously, we discovered that …

Recent years have provided considerable insights into the dynamic nature of the cell
nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well …

The actin cytoskeleton is of fundamental importance for numerous cellular processes,
including intracellular transport, cell plasticity, and cell migration. However, functions of …

Actin has essential functions both in the cytoplasm and in the nucleus, where it has been
linked to key nuclear processes, from transcription to DNA damage response. The …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …