Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Overcoming the restricted axonal regenerative ability that limits functional repair following a
central nervous system injury remains a challenge. Here we report a regenerative paradigm …

The immune system plays an indispensable role in the process of tissue regeneration
following damage as well as during homeostasis. Inflammation and immune cell recruitment …

For ages, regeneration has intrigued countless biologists, clinicians, and biomedical
engineers. In recent years, significant progress made in identification and characterization of …

Growth and destruction are central components of the neuronal injury response. Injured
axons that are capable of repair, including axons in the mammalian peripheral nervous …

Functional regeneration after axonal injury requires transected axons to regrow and
reestablish connection with their original target tissue. The spontaneous regenerative …

In this study a robust, whole organism screening based on Caenorhabditis elegans is
presented for the discovery of natural products (NP) with beneficial effects against obesity …

Unlike many cell types, neurons are not typically replaced if damaged. Therefore,
regeneration of damaged cellular domains is critical for maintenance of neuronal function …

Identifying novel marine-derived neuroactive chemicals with therapeutic potential is difficult
due to inherent complexities of the central nervous system (CNS), our limited understanding …