Advances in measuring cancer cell metabolism with subcellular resolution
Characterizing metabolism in cancer is crucial for understanding tumor biology and for
developing potential therapies. Although most metabolic investigations analyze averaged …
developing potential therapies. Although most metabolic investigations analyze averaged …
[HTML][HTML] The role of the Golgi apparatus in disease
J Liu, Y Huang, T Li, Z Jiang… - … journal of molecular …, 2021 - spandidos-publications.com
The Golgi apparatus is known to underpin many important cellular homeostatic functions,
including trafficking, sorting and modifications of proteins or lipids. These functions are …
including trafficking, sorting and modifications of proteins or lipids. These functions are …
[HTML][HTML] Lipids and their trafficking: an integral part of cellular organization
CL Jackson, L Walch, JM Verbavatz - Developmental cell, 2016 - cell.com
An evolutionarily conserved feature of cellular organelles is the distinct phospholipid
composition of their bounding membranes, which is essential to their identity and function …
composition of their bounding membranes, which is essential to their identity and function …
The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)
MG Waugh - Biochemical journal, 2019 - portlandpress.com
Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …
[HTML][HTML] Punicalagin in cancer prevention—via signaling pathways targeting
I Berdowska, M Matusiewicz, I Fecka - Nutrients, 2021 - mdpi.com
The extract of pomegranate (Punica granatum) has been applied in medicine since ancient
times due to its broad-spectrum health-beneficial properties. It is a rich source of …
times due to its broad-spectrum health-beneficial properties. It is a rich source of …
[HTML][HTML] Oncogenic roles of GOLPH3 in the physiopathology of cancer
S Sechi, A Frappaolo… - International journal of …, 2020 - mdpi.com
Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI (4) P] effector at
the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi …
the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi …
[HTML][HTML] APOL1 C-terminal variants may trigger kidney disease through interference with APOL3 control of actomyosin
S Uzureau, L Lecordier, P Uzureau, D Hennig… - Cell reports, 2020 - cell.com
The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …
[HTML][HTML] GOLPH3: a Golgi phosphatidylinositol (4) phosphate effector that directs vesicle trafficking and drives cancer
RS Kuna, SJ Field - Journal of lipid research, 2019 - ASBMB
GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its
purpose had been unclear. We found that GOLPH3 binds specifically to the …
purpose had been unclear. We found that GOLPH3 binds specifically to the …
Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport
LM Del Bel, JA Brill - Traffic, 2018 - Wiley Online Library
The lipid phosphatase Sac1 dephosphorylates phosphatidylinositol 4‐phosphate (PI4P),
thereby holding levels of this crucial membrane signaling molecule in check. Sac1 regulates …
thereby holding levels of this crucial membrane signaling molecule in check. Sac1 regulates …
The core autophagy protein ATG9A controls dynamics of cell protrusions and directed migration
D Campisi, L Desrues, KP Dembélé, A Mutel… - Journal of Cell …, 2022 - rupress.org
Chemotactic migration is a fundamental cellular behavior relying on the coordinated flux of
lipids and cargo proteins toward the leading edge. We found here that the core autophagy …
lipids and cargo proteins toward the leading edge. We found here that the core autophagy …