Characterizing metabolism in cancer is crucial for understanding tumor biology and for
developing potential therapies. Although most metabolic investigations analyze averaged …

The Golgi apparatus is known to underpin many important cellular homeostatic functions,
including trafficking, sorting and modifications of proteins or lipids. These functions are …

An evolutionarily conserved feature of cellular organelles is the distinct phospholipid
composition of their bounding membranes, which is essential to their identity and function …

Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

The extract of pomegranate (Punica granatum) has been applied in medicine since ancient
times due to its broad-spectrum health-beneficial properties. It is a rich source of …

Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI (4) P] effector at
the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi …

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …

GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its
purpose had been unclear. We found that GOLPH3 binds specifically to the …

The lipid phosphatase Sac1 dephosphorylates phosphatidylinositol 4‐phosphate (PI4P),
thereby holding levels of this crucial membrane signaling molecule in check. Sac1 regulates …

Chemotactic migration is a fundamental cellular behavior relying on the coordinated flux of
lipids and cargo proteins toward the leading edge. We found here that the core autophagy …