Ethnopharmacological relevance The prevalence of diabetes is on a steady increase
worldwide and it is now identified as one of the main threats to human health in the 21st …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Natural as well as synthetic coumarins have recently drawn much attention due to its broad
pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti …

CME sequently, CYP3A4 activity in the small intestine is impaired until de novo synthesis
returns the enzyme to its previous level. This mechanism explains the important clinical …

Objectives Our objective was to examine the effect of different fruits and their constituents on
P‐glycoprotein and organic anion transporting polypeptide (OATP) activities in vitro and on …

Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

We showed previously that grapefruit and orange juices inhibited human enteric organic
anion‐transporting polypeptide (OATP) 1A2 in vitro and lowered oral fexofenadine …

Obesity is a major health problem facing the developed and developing world. Efforts by
individuals, health professionals, educators, and policy makers to combat the escalating …