Placental galectins in cancer: why we should pay more attention
C Fuselier, A Dumoulin, A Paré, R Nehmé, S Ajarrag… - Cells, 2023 - mdpi.com
The first studies suggesting that abnormal expression of galectins is associated with cancer
were published more than 30 years ago. Today, the role of galectins in cancer is relatively …
were published more than 30 years ago. Today, the role of galectins in cancer is relatively …
Chimera and tandem-repeat type galectins: the new targets for cancer immunotherapy
FCF Ko, S Yan, KW Lee, SK Lam, JCM Ho - Biomolecules, 2023 - mdpi.com
In humans, a total of 12 galectins have been identified. Their intracellular and extracellular
biological functions are explored and discussed in this review. These galectins play …
biological functions are explored and discussed in this review. These galectins play …
The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation
R Tazhitdinova, AV Timoshenko - Cells, 2020 - mdpi.com
Galectins are a family of soluble β-galactoside-binding proteins with diverse glycan-
dependent and glycan-independent functions outside and inside the cell. Human cells …
dependent and glycan-independent functions outside and inside the cell. Human cells …
Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity
Y Si, Y Yao, GJ Ayala, X Li, Q Han, W Zhang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background The structure of human galectin-16 (Gal-16) has yet to be solved, and its
function has remained elusive. Methods X-ray crystallography was used to determine the …
function has remained elusive. Methods X-ray crystallography was used to determine the …
The interrelation of galectins and autophagy
L Zheng, J Xia, P Ge, Y Meng, W Li, M Li… - International …, 2023 - Elsevier
Autophagy is a vital physiological process that maintains intracellular homeostasis by
removing damaged organelles and senescent or misfolded molecules. However, excessive …
removing damaged organelles and senescent or misfolded molecules. However, excessive …
Structure–function studies of galectin‐14, an important effector molecule in embryology
Y Si, Y Li, T Yang, X Li, GJ Ayala, KH Mayo… - The FEBS …, 2021 - Wiley Online Library
The expression of prototype galectin‐14 (Gal‐14) in human placenta is higher than any
other galectin, suggesting that it may play a role in fetal development and regulation of …
other galectin, suggesting that it may play a role in fetal development and regulation of …
Intracellular galectin interactions in health and disease
R Jacob, LS Gorek - Seminars in Immunopathology, 2024 - Springer
In the galectin family, a group of lectins is united by their evolutionarily conserved
carbohydrate recognition domains. These polypeptides play a role in various cellular …
carbohydrate recognition domains. These polypeptides play a role in various cellular …
Peptide triazole inhibitors of HIV-1: hijackers of env metastability
EP Carter, CG Ang, IM Chaiken - Current Protein and Peptide …, 2023 - ingentaconnect.com
With 1.5 million new infections and 690,000 AIDS-related deaths globally each year, HIV-1
remains a pathogen of significant public health concern. Although a wide array of effective …
remains a pathogen of significant public health concern. Although a wide array of effective …
Placental galectins: a subfamily of galectins lose the ability to bind β-galactosides with new structural features
X Pei, J Zhu, Y Wang, F Zhang, Y He… - Biology of …, 2023 - academic.oup.com
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins.
There are 16 different of galectins, each with a specific function determined by its distinct …
There are 16 different of galectins, each with a specific function determined by its distinct …
[HTML][HTML] Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma: Effects of glutathione on …
H Na, H Sayed, GJ Ayala, X Wang, Y Liu… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
Abstract Charcot-Leyden crystals (CLCs) are the hallmark of many eosinophilic-based
diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs …
diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs …