In recent years, proteolysis-targeting chimeras (PROTACs), capable of achieving targeted
protein degradation, have proven their great therapeutic potential and usefulness as …

Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new
and exciting class of therapeutic agents that promise to significantly impact drug discovery …

Cyclin-dependent kinase 6 (CDK6) is an important regulator of the cell cycle. Together with
CDK4, it phosphorylates and inactivates retinoblastoma (Rb) protein. In tumour cells, CDK6 …

Targeted protein degradation (TPD) has emerged as a promising approach for drug
development, particularly for undruggable targets. TPD technology has also been …

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as
the primary therapeutic paradigm targeting pathogenic proteins. However, their efficacy …

Background: This study aimed to investigate the aberrant expression of hsa_circ_0002874
in non-small cell lung cancer (NSCLC) and elucidate associated molecular mechanisms that …

A repertoire of proteolysis-targeting signals known as degrons is a necessary component of
protein homeostasis in every living cell. In bacteria, degrons can be used in place of …

Targeted protein degradation (TPD) holds great promise for biological inquiry and
therapeutic development. However, it still remains elusive to destruct DNA/RNA binding …

Steroid receptor coactivator-1 (SRC-1) is a transcription coactivator playing a pivotal role in
mediating a wide range of signaling pathways by interacting with related transcription factors …

Posttranslational modifications (PTMs) play an important role in cell signaling and they are
often deregulated in disease. This review addresses recent advances in the development of …