Nanomedicine as a potent strategy in melanoma tumor microenvironment
Melanoma originated from melanocytes is the most aggressive type of skin cancer. Despite
considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors …
considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors …
[HTML][HTML] Chemokine pathways in cutaneous melanoma: their modulation by cancer and exploitation by the clinician
R Adams, B Moser, SN Karagiannis, KE Lacy - Cancers, 2021 - mdpi.com
Simple Summary Despite significant advances in immunotherapy seen in the last decade,
melanoma accounts for 2500 deaths a year in the UK. There remains an unmet clinical need …
melanoma accounts for 2500 deaths a year in the UK. There remains an unmet clinical need …
[HTML][HTML] Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo
H He, C Schönmann, M Schwarz, B Hindelang… - Nature …, 2022 - nature.com
Melanoma is associated with angiogenesis and vascular changes that may extend through
the entire skin depth. Three-dimensional imaging of vascular characteristics in skin lesions …
the entire skin depth. Three-dimensional imaging of vascular characteristics in skin lesions …
Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma
Metastatic melanoma is highly fatal. Within the tumor microenvironment, the role of cancer-
associated fibroblasts (CAFs) in melanoma metastasis and progression is relatively …
associated fibroblasts (CAFs) in melanoma metastasis and progression is relatively …
Dynamic optical coherence tomography shows characteristic alterations of blood vessels in malignant melanoma
J Welzel, S Schuh, N De Carvalho… - Journal of the …, 2021 - Wiley Online Library
Background Dynamic optical coherence tomography (D‐OCT) allows in vivo visualization of
blood vessels in the skin and in malignant tumours. Vessel patterns in malignant melanoma …
blood vessels in the skin and in malignant tumours. Vessel patterns in malignant melanoma …
[HTML][HTML] Anti-Tumoral and Anti-Angiogenic Effects of Low-Diluted Phenacetinum on Melanoma
C Fuselier, S Quemener, E Dufay, C Bour… - Frontiers in …, 2021 - frontiersin.org
Melanoma is the most aggressive form of skin cancer and the most rapidly expanding
cancer in terms of worldwide incidence. If primary cutaneous melanoma is mostly treated …
cancer in terms of worldwide incidence. If primary cutaneous melanoma is mostly treated …
Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma
SX Tan, S Chong, C Rowe, J Galbraith… - Experimental …, 2024 - Wiley Online Library
Lymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a
higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective …
higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective …
[HTML][HTML] Preventing calpain externalization by reducing ABCA1 activity with probenecid limits melanoma angiogenesis and development
G Hanouna, E Tang, J Perez, S Vandermeersch… - Journal of Investigative …, 2020 - Elsevier
Calpains, intracellular proteases specifically inhibited by calpastatin, play a major role in
neoangiogenesis involved in tumor invasiveness and metastasis. They are partly …
neoangiogenesis involved in tumor invasiveness and metastasis. They are partly …
Squamous cell carcinomas of the skin explore angiogenesis‐independent mechanisms of tumour vascularization
I Pastushenko, T Gracia-Cazaña… - Journal of skin …, 2014 - Wiley Online Library
Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell
carcinomas (SCCs) of the skin. Methods. We performed CD31 (ie, panendothelial marker) …
carcinomas (SCCs) of the skin. Methods. We performed CD31 (ie, panendothelial marker) …
Gene expression differences predict treatment outcome of merkel cell carcinoma patients
L Masterson, BJ Thibodeau, LE Fortier… - Journal of Skin …, 2014 - Wiley Online Library
Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been
practical. This study aimed to identify biomarkers with prognostic significance. While sixty …
practical. This study aimed to identify biomarkers with prognostic significance. While sixty …