Melanoma originated from melanocytes is the most aggressive type of skin cancer. Despite
considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors …

Simple Summary Despite significant advances in immunotherapy seen in the last decade,
melanoma accounts for 2500 deaths a year in the UK. There remains an unmet clinical need …

Melanoma is associated with angiogenesis and vascular changes that may extend through
the entire skin depth. Three-dimensional imaging of vascular characteristics in skin lesions …

Metastatic melanoma is highly fatal. Within the tumor microenvironment, the role of cancer-
associated fibroblasts (CAFs) in melanoma metastasis and progression is relatively …

Background Dynamic optical coherence tomography (D‐OCT) allows in vivo visualization of
blood vessels in the skin and in malignant tumours. Vessel patterns in malignant melanoma …

Melanoma is the most aggressive form of skin cancer and the most rapidly expanding
cancer in terms of worldwide incidence. If primary cutaneous melanoma is mostly treated …

Lymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a
higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective …

Calpains, intracellular proteases specifically inhibited by calpastatin, play a major role in
neoangiogenesis involved in tumor invasiveness and metastasis. They are partly …

Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell
carcinomas (SCCs) of the skin. Methods. We performed CD31 (ie, panendothelial marker) …

Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been
practical. This study aimed to identify biomarkers with prognostic significance. While sixty …